Archive for July 2025

Why These Neurons? Why This Patient? Why Now? Selective vulnerability in neurodegeneration has puzzled neurologists for decades. At the Alzheimer’s Association International Conference of 2025, we describe some computational neuroscience network models that attempt to address these questions with a hypothesis called Thermodynamic-Informational Entropic Relationships (TIER). We turned to physics—specifically thermodynamic entropy—to understand why systems…